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KMID : 1161520000040020173
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Animal Cells and Systems
2000 Volume.4 No. 2 p.173 ~ p.179
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Changes in the hypothalamic gonadotropin-releasing hormone gene expression and the pituitary luteinizing hormone immunoreactivity in male rats: Comparison of clozapine with typical antipsychotics
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Kim Myeong-Ok
Koh Phil-Ok
Kim Jin-Hyun
Chung Ki-Myung
Kang Sang-Soo
Choi Wan-Sung
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Abstract
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Evidence suggested that atypical antipsychotics (APs) such as clozapine show less side effects than those of typical APs such as haloperidol and sulpiride. However, little is known about chronic effects of these drugs on changes in gonadotropin releasing hormone (GnRH) mRNA expression and luteinizing hormone (LH) immunoreactivity. Male rats were divided into water?, haloperidol?, sulpiride?, and clozapine?treated groups, and these drugs were administered orally for 4 weeks. The changes in the expression of GnRH mRNA and the LH immunoreactivity were determined in the hypothalamus and pituitary, respectively, using in situ hybridization and immun?ohistochemistry. GnRH mRNAs were clearly expressed in the water?treated control rats. This was significantly reduced by the chronic treatments with the typical APs, especially with haioperidoi, but not with atypical APs clozapine. Likewise, LH immunoreactivity was clearly stained in the control group. While its immunoreativity was significantly reduced by the chronic APs treatments, clozapine treatment showed only slight attenuation. The results show that the atypicaj APs clozapine has less side effects in the gonadal function than the typical APs haloperidol and the suipiride. These results suggest that clozapine is a safer drug than the typical APs, at least in the reproductive system.
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KEYWORD
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Antipsychotics, GnRH, LH, In situ hybridization, Hypothalamus, Pituitary
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